Open AccessMetformin Treatment Alters Memory Function in a Mouse Model of Alzheimer's Disease
Author(s) -
Kacee A DiTacchio,
Stephen F. Heinemann,
Gustavo Dziewczapolski
Publication year - 2015
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-141332
Subject(s) - ampk , disease , metformin , diabetes mellitus , medicine , intervention (counseling) , cognition , type 2 diabetes , memory impairment , neuroscience , alzheimer's disease , bioinformatics , psychology , endocrinology , psychiatry , biology , protein kinase a , biochemistry , enzyme
Metabolic dysfunction exacerbates Alzheimer's disease (AD) incidence and progression. Here we report that activation of the AMPK pathway, a common target in the management of diabetes, results in gender-divergent cognitive effects in a murine model of the disease. Specifically, our results show that activation of AMPK increases memory dysfunction in males but is protective in females, suggesting that gender considerations may constitute an important factor in medical intervention of diabetes as well as AD.