Open AccessA formalization of one of the main claims of “The cancer glycocalyx mechanically primes integrin-mediated growth and survival” by Paszek et al. 20141
Author(s) -
Russell Bainer
Publication year - 2022
Publication title -
data science
Language(s) - English
Resource type - Journals
eISSN - 2451-8492
pISSN - 2451-8484
DOI - 10.3233/ds-210050
Subject(s) - glycocalyx , context (archaeology) , integrin , extracellular matrix , class (philosophy) , cancer cell , microbiology and biotechnology , cell , cancer , chemistry , biology , cancer research , computer science , biochemistry , genetics , artificial intelligence , paleontology
Paszek et al. claimed in previous work that glycocalyx bulk mechanically drives integrin clustering in cancer cells engaged with the extracellular matrix. We present here a formalization of that claim, stating that all things of class “glycocalyx bulk” that are in the context of a thing of class “ecm bound cancer cell” generally have a relation of type “increases” to a thing of class “integrin clustering” in the same context.