Open AccessA formalization of one of the main claims of “ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair” by Klim et al. 20191
Author(s) -
B. Nolan Nichols
Publication year - 2022
Publication title -
data science
Language(s) - English
Resource type - Journals
eISSN - 2451-8492
pISSN - 2451-8484
DOI - 10.3233/ds-210039
Subject(s) - mediator , motor neuron , transcription (linguistics) , context (archaeology) , biology , class (philosophy) , neuroscience , neuron , relation (database) , microbiology and biotechnology , computer science , philosophy , artificial intelligence , linguistics , paleontology , database , spinal cord
Klim et al. claimed in previous work that the protein TDP-43 generally contributes to the transcription of STMN2 in human motor neurons. We present here a formalization of that claim, stating that all things of class “TAR DNA binding protein” that are in the context of a thing of class “human motor neuron” can generally have a relation of type “contributes to” to a thing of class “transcription of stmn2” in the same context.