Open AccessCan erythrocytes behavior in microcirculation help the understanding the physiopathology and improve prevention and treatment for covid-19?
Author(s) -
Paulo Luiz Farber
Publication year - 2021
Publication title -
clinical hemorheology and microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 54
eISSN - 1875-8622
pISSN - 1386-0291
DOI - 10.3233/ch-201082
Subject(s) - microcirculation , erythrocyte deformability , blood viscosity , erythrocyte aggregation , medicine , diabetes mellitus , hypoxia (environmental) , hemorheology , covid-19 , red blood cell , pathophysiology , endocrinology , physiology , disease , chemistry , hematocrit , infectious disease (medical specialty) , organic chemistry , oxygen
Low plasma estrogens, vitamin D deficiency, obesity, diabetes, cardiovascular diseases, thromboembolism, and impaired microcirculation are linked to the severity of covid-19. Studies have suggested that these comorbidities also are related to erythrocyte factors linked to increased blood viscosity in microcirculation such as erythrocyte aggregation and erythrocyte deformability. Increased blood viscosity in microcirculation can lead to a decrease in oxygenation and nutrition of tissues. Therefore erythrocyte aggregation and erythrocyte deformability may be involved in covid-19 severity, leading to tissue hypoxia and a decrease of drug concentration in affected organs. If this relationship is demonstrated, erythrocytes factors can be used to monitor treatments for improve microcirculatory fluidity that may decrease covid-19 severity. Lifestyle improvement and treatments such as vitamin D and estrogens supplementation are some possible approaches to improve microcirculation and covid-19 prevention and treatment.