Open AccessPreliminary Evidence of Improvement in Adolescent and Young Adult Cancer Survivors’ Brain Health Following Physical Activity: A Proof-of-Concept Sub-Study
Author(s) -
Maude Lambert,
Amanda Wurz,
Andra Smith,
Zhuo Fang,
Jennifer Brunet
Publication year - 2021
Publication title -
brain plasticity
Language(s) - English
Resource type - Journals
eISSN - 2213-6312
pISSN - 2213-6304
DOI - 10.3233/bpl-210124
Subject(s) - medicine , randomized controlled trial , fractional anisotropy , randomization , young adult , physical therapy , intervention (counseling) , diffusion mri , magnetic resonance imaging , psychiatry , radiology
Cognitive impairment is common among adolescent and young adult (AYA) cancer survivors. Physical activity (PA) may help mitigate cognitive impairment post-treatment by positively impacting two indicators of general brain health: fractional anisotropy (FA) and functional connectivity (FC). As part of a two-arm, mixed-methods pilot randomized controlled trial (RCT), this sub-study was designed to provide preliminary proof-of-concept evidence for the effects of PA on FA and FC among AYA cancer survivors post-treatment to help inform decisions about proceeding to larger trials.