z-logo
open-access-imgOpen Access
Qualitative Analysis of Pain in Patients With Locally Advanced or Metastatic Urothelial Carcinoma
Author(s) -
Susan Martin,
Sonali Shah,
Zsolt Hepp,
Nimanee Harris,
Alicia K. Morgans
Publication year - 2022
Publication title -
bladder cancer
Language(s) - English
Resource type - Journals
eISSN - 2352-3735
pISSN - 2352-3727
DOI - 10.3233/blc-211518
Subject(s) - medicine , brief pain inventory , physical therapy , pain assessment , debriefing , quality of life (healthcare) , cancer pain , pain scale , pain medicine , cancer , pain management , anesthesia , chronic pain , nursing , anesthesiology , medical education
BACKGROUND: Pain is not well described in patients with locally advanced or metastatic urothelial cancer (la/mUC). OBJECTIVE: To characterize pain and assess the content validity of the Brief Pain Inventory Short Form (BPI-SF) worst pain item in patients with la/mUC receiving first-line treatment in the US. METHODS: Qualitative interviews were conducted in patients aged≥45 years with confirmed la/mUC, self-reported la/mUC-attributed pain before enrollment, and no major surgery≤3 months prior to being interviewed. Interview participants were asked open-ended questions about their la/mUC symptoms and pain. “Think aloud” cognitive debriefing was conducted for the BPI-SF worst pain item. RESULTS: Ten participants with laUC and six (38%) with mUC were interviewed. First-line treatments included cisplatin (n = 14; 88%) or carboplatin (n = 2; 13%). The average past-week worst pain score (0–10 scale) was 6.2 (range, 3–10); seven (44%) participants reported severe pain (score≥7). Pain was most frequently reported in the back (n = 14; 88%) and/or pelvic/lower abdominal area (n = 10; 63%). Pain impacted all participants’ physical and daily activities; 81% reported it impacted their overall quality of life. All participants interpreted and completed the BPI-SF worst pain item without difficulty; 15 (94%) reported it was relevant to their la/mUC experience. Participants understood the 24-hour recall period; most supported daily (n = 13; 81%) or weekly (n = 14; 88%) assessment, preferring electronic administration using their phone (n = 14; 88%). CONCLUSIONS: Pain attributed to la/mUC impacted physical and daily activities in all participants undergoing first-line treatment for la/mUC. Content validity was demonstrated for the BPI-SF worst pain item in this population.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here