Open AccessWhen tumor doesn’t read textbook. Third case of TTF1 and p40 co-expression in the same tumour cells in a non-small cell carcinoma. A potential new entity to consider?
Author(s) -
M Spinelli,
Jamshid S Khorshad,
Patrizia Viola
Publication year - 2019
Publication title -
pathologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.243
H-Index - 18
eISSN - 1591-951X
pISSN - 0031-2983
DOI - 10.32074/1591-951x-12-19
Subject(s) - immunohistochemistry , adenocarcinoma , oncogene , lung cancer , basal cell , pathology , stage (stratigraphy) , carcinoma , medicine , cancer , cancer research , cell , oncology , biology , cell cycle , paleontology , genetics
The 2011 WHO Classification for lung adenocarcinoma enlightened the need for a wise use of immunohistochemistry to preserve tissue for both diagnosis and molecular studies. The current recommendation is to use a panel comprising TTF1 and p40 to classify tumors with no clear squamous or glandular differentiation as many studies have showed the higher specificity of p40 over p63 as marker of squamous differentiation. However, the co-expression of both markers opens a new scenario with subsequent classification and potentially treatment issues.