Open AccessDiagnostic test assessment. Validation study of an alternative system to detect microsatellite instability in colorectal carcinoma
Author(s) -
Simona Vatrano,
Angela Pettinato,
Valentina Randazzo,
Marina Zagami,
Cecilia Agueli,
Sonia Cannella,
Giuseppe Luigi Banna,
Filippo Fraggetta,
Alessandra Santoro
Publication year - 2020
Publication title -
pathologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.243
H-Index - 18
eISSN - 1591-951X
pISSN - 0031-2983
DOI - 10.32074/1591-951x-113
Subject(s) - microsatellite instability , concordance , colorectal cancer , medicine , oncology , lynch syndrome , microsatellite , biomarker , molecular biomarkers , dna mismatch repair , pathology , cancer , biology , biochemistry , allele , gene
The American Society for Clinical Pathology (ASCP), College of American Pathologists (CAP), Association for Molecular Pathology (AMP), and the American Society of Clinical Oncology (ASCO) have been recently strongly recommended the evaluation of mismatch repair status (MMS) as molecular biomarkers in colorectal cancer for a better prognostic stratification of patients. This recommendation is emphasized by the recent evidence of Microsatellite Instability (MSI) as a predictive marker for chemotherapy and immunotherapy.