Open AccessENCAPSULATION OF VITAMIN AEVIT OIL SOLUTION WITH β-CYCLODEXTRIN
Author(s) -
Ainara Iskineyeva,
A. Mustafayeva,
G. Zamaratskaya,
A.Zh. Sarsenbekova,
С. Д. Фазылов,
М. Ж. Буркеев,
О. А. Нуркенов,
Т. М. Сейлханов,
Ryszhan Bakirova
Publication year - 2021
Publication title -
doklady nacionalʹnoj akademii nauk respubliki kazahstan
Language(s) - English
Resource type - Journals
eISSN - 2518-1483
pISSN - 2224-5227
DOI - 10.32014/2021.2518-1483.1
Subject(s) - differential scanning calorimetry , cyclodextrin , clathrate hydrate , chemistry , scanning electron microscope , inclusion compound , chemical engineering , aqueous solution , thermal decomposition , organic chemistry , analytical chemistry (journal) , materials science , thermodynamics , hydrate , composite material , physics , engineering
The present work aimed at encapsulation of fat-soluble vitamin Aevit (vitamins A and E, oil) withβ-cyclodextrin. Inclusion complex of vitamins A and E with β-cyclodextrin was prepared in an aqueous alcohol medium by ultrasonic treatment. The surface morphology of the resulting clathrate inclusion complexes was described using a scanning electron microscope. The results of thermographic measurements on a differential scanning calorimeter are presented. The spectral properties of the inclusion complex are characterized by 1H and 13C NMR spectroscopy data. The experimental results confirmed the existence of a complex of inclusion ofβ-cyclodextrin with vitamin Aevit (2:1). The activation energy of the thermooxidation destruction reaction of the clathrate complex β-cyclodextrin:vitamin Aevit was calculated, kinetic parameters of thermal destruction of clathrate were determined. These parameters were determined based on the Freeman-Carroll, Sharpe-Wentworth, Ahar and Coates-Redfern methods. The use of the above models made it possible to graphically establish the thermodynamic parameters of the thermal decomposition of β-cyclodextrin and its clathrate with vitamin. The data of thermographic measurements on a differential scanning calorimeter showed that the thermal destruction of the Aevite clathrate with β-cyclodextrin begins with the removal of water molecules from the β-cyclodextrin cavity, then the “guest” substance and the cyclic oligosaccharide are destroyed.