Open AccessReplication in Human Intestinal Enteroids of Infectious Norovirus from Vomit Samples
Author(s) -
Marie Hagbom,
Jenny Lin,
Tina Falkeborn,
Lena Serrander,
Jan Albert,
Johan Nordgren,
Sumit Sharma
Publication year - 2021
Publication title -
emerging infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.54
H-Index - 226
eISSN - 1080-6059
pISSN - 1080-6040
DOI - 10.3201/eid2708.210011
Subject(s) - norovirus , virology , murine norovirus , infectivity , biology , microbiology and biotechnology , diarrhea , viral replication , acute gastroenteritis , human bocavirus , vomiting , virus , medicine , respiratory system , respiratory tract infections , pathology , surgery , anatomy
A typical clinical symptom of human norovirus infection is projectile vomiting. Although norovirus RNA and viral particles have been detected in vomitus, infectivity has not yet been reported. We detected replication-competent norovirus in 25% of vomit samples with a 13-fold to 714-fold increase in genomic equivalents, confirming infectious norovirus.