Open AccessBat-transmitted Human Rabies Outbreaks, Brazilian Amazon
Author(s) -
Elizabeth Salbé Travassos da Rosa,
Ivanete Kotait,
Taciana Fernandes Souza Barbosa,
Maria Luíza Carrieri,
Paulo Eduardo Brandão,
Amiraldo S. Pinheiro,
Alberto L. Begot,
Marcelo Yoshito Wada,
Rosely Cerqueira de Oliveira,
Edmundo C. Grisard,
Márcia Ferreira,
Reynaldo José da Silva Lima,
Lúcia Montebello,
Daniele B. A. Medeiros,
Rita Catarina Medeiros Sousa,
Gilberta Bensabath,
Eduardo Hage Carmo,
Pedro F. C. Vasconcelos
Publication year - 2006
Publication title -
emerging infectious diseases
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.54
H-Index - 226
eISSN - 1080-6059
pISSN - 1080-6040
DOI - 10.3201/eid1208.050929
Subject(s) - rabies , desmodus rotundus , virology , rabies virus , outbreak , biology , rhabdoviridae , virus , mononegavirales , amazon rainforest , viral disease , paramyxoviridae , ecology
We describe 2 bat-transmitted outbreaks in remote, rural areas of Portel and Viseu Municipalities, Pará State, northern Brazil. Central nervous system specimens were taken after patients' deaths and underwent immunofluorescent assay and histopathologic examination for rabies antigens; also, specimens were injected intracerebrally into suckling mice in an attempt to isolate the virus. Strains obtained were antigenically and genetically characterized. Twenty-one persons died due to paralytic rabies in the 2 municipalities. Ten rabies virus strains were isolated from human specimens; 2 other cases were diagnosed by histopathologic examination. Isolates were antigenically characterized as Desmodus rotundus variant 3 (AgV3). DNA sequencing of 6 strains showed that they were genetically close to D. rotundus-related strains isolated in Brazil. The genetic results were similar to those obtained by using monoclonal antibodies and support the conclusion that the isolates studied belong to the same rabies cycle, the virus variants found in the vampire bat D. rotundus.