Open AccessMolecular Interaction of Chili Compounds (Capsicum annum L) as a COX-2 Inhibitor
Author(s) -
Yohanes Bare,
Nurul Imaniyah Ahmad,
Yohanes g Bunga
Publication year - 2022
Publication title -
jurnal mangifera edu
Language(s) - English
Resource type - Journals
eISSN - 2622-3384
pISSN - 2527-9939
DOI - 10.31943/mangiferaedu.v6i2.124
Subject(s) - pubchem , capsaicin , chili pepper , chemistry , antiseptic , traditional medicine , food science , pepper , biochemistry , medicine , organic chemistry , receptor
Curly red chili (Capsicum annum L.) is a vegetable that has health benefits. Besides being used as an addictive substance in traditional medicine, Capsicum annum L. is also used for cough treatment, antiseptic, anti-irritant, anti-inflammatory. This research study aims to analyze the physico-chemical and its molecular interactions with COX-2. Capsaicin (CID: 1548943), dihydrocapsaicin (CID: 107982) and homocapsaicin (CID: 6442566) compounds were downloaded from pubchem. While the COX protein (ID: 6cox) from the Protein Data Bank. Molecular interaction and analized by HEX. 8.0.0 and Discovery Studio. The three compounds contained in curly red chilies have unique physico-chemical characteristics. The results of the interaction show that the curly mera chili has a physiological function by inhibiting the performance of COX-2