Open AccessEFEKTIVITAS FRAKSI AKTIF EKSTRAK ETANOL LABU SIAM (Sechium edule (Jack) Sw) SEBAGAI ANTIHIPERTENSI PADA TIKUS HIPERTENSI YANG DIINDUKSI MONOSODIUM GLUTAMAT
Author(s) -
Yance Anas,
Ika Nilam Cahyani,
Ulum Firnanda Sukma
Publication year - 2021
Publication title -
jurnal ilmu farmasi dan farmasi klinik/jurnal ilmu farmasi and farmasi klinik
Language(s) - English
Resource type - Journals
eISSN - 2716-3814
pISSN - 1693-7899
DOI - 10.31942/jiffk.v18i01.4893
Subject(s) - monosodium glutamate , ethyl acetate , chemistry , ethanol , traditional medicine , maceration (sewage) , food science , chromatography , medicine , biochemistry , materials science , composite material
Previous studies accomplished that the chayote ethanol extract (Sechium edule (Jack) Sw) had an
antihypertensive effect. To get and identify the active compound, we fractionated the extract and
evaluated its antihypertensive activity. This study aims to investigate the antihypertensive effect of
the n-hexane fraction (HF-CEE) and ethyl acetate fraction of chayote ethanol extract (EAF-CEE)
in monosodium glutamate (MSG)-induced hypertensive rats. We made the chayote extract using the
maceration method by soaking the chayote simplicia in ethanol 70%. HF-CEE and EAF-CEE were
obtained by stratified fractionation using n-hexane and ethyl acetate. An antihypertensive effect of
the fraction measured on MSG-induced hypertension male Wistar rats after MSG 100 mg/kg
BW/day (p.o) treatment for 14 days. The study concluded that HF-CEE and EAF-CEE had an
antihypertensive effect in MSG-induced hypertensive rats. The EAF-CEE antihypertensive effect is
higher than HF-CEE. Therefore, the FEAF-CEE active compounds need to be isolated, identified,
developed, and their potential as an antihypertensive candidate.
Keywords: Antihypertensive, chayote, ethyl-acetate fraction, Sechium edule, monosodium
glutamate