Open AccessAntiarrhythmic drugs: mechanisms of action, clinical effects, indications for use
Author(s) -
G. M. Solovyan,
Т. В. Міхалєва
Publication year - 2019
Publication title -
ukraïnsʹkij kardìologìčnij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2664-4479
pISSN - 1608-635X
DOI - 10.31928/1608-635x-2019.2.7690
Subject(s) - medicine , clinical practice , anti arrhythmia agents , action (physics) , mechanism of action , mechanism (biology) , cardiology , pharmacology , neuroscience , intensive care medicine , atrial fibrillation , psychology , chemistry , biochemistry , physics , philosophy , family medicine , epistemology , quantum mechanics , in vitro
The lecture is devoted to one of the most difficult problems of modern cardiology – the use of antiarrhythmic therapy in clinical practice. The basic mechanisms of arrhythmias, aspects of their onset, maintenance and termination are briefly described. The current evidence on the electrophysiological mechanisms of cardiac arrhythmias – re-entry, abnormal impulse formation, and trigger activity – is presented. The article contains information about the remodeling of ion channels properties. The Sicilian gambit is analyzed, in which the mechanisms of arrhythmias are compared to the mechanisms of anti-arrhythmic action of drugs. Classification of anti-arrhythmic drugs, their mechanisms of action, indications and contraindications, side effects, and interaction with other drugs are presented.