Open AccessTherapeutic Targets of Tumor Metabolism
Author(s) -
Vyacheslav A. Chubenko
Publication year - 2021
Publication title -
praktičeskaâ onkologiâ
Language(s) - English
Resource type - Journals
eISSN - 1726-9830
pISSN - 1726-9814
DOI - 10.31917/2203183
Subject(s) - autophagy , hypoxia (environmental) , tumor microenvironment , glycolysis , phenotype , metabolism , biology , tumor cells , pinocytosis , lipid metabolism , cell metabolism , cancer research , reprogramming , metabolic pathway , bioenergetics , energy metabolism , mitochondrion , microbiology and biotechnology , anaerobic glycolysis , cell , chemistry , biochemistry , apoptosis , endocytosis , endocrinology , gene , organic chemistry , oxygen
Tumor cell metabolism has certain distinctive features such as aerobic glycolysis, utilization of alternative energy sources, increased lipid synthesis, mitochondrial dysfunction, macropinocytosis, autophagy, high levels of ROS, tumor microenvironment and hypoxia. This heterogeneity is determined by the malignant phenotype and the environmental conditions. Targeting specific metabolic pathways may be a promising treatment to increase the overall survival. This paper demonstrates the metabolic reprogramming as the potential anticancer strategy.