Open AccessCOMBINATIONS OF IMMUNOTHERAPY AND OTHER DRUGS
Author(s) -
В. А. Чубенко
Publication year - 2021
Publication title -
praktičeskaâ onkologiâ
Language(s) - English
Resource type - Journals
eISSN - 1726-9830
pISSN - 1726-9814
DOI - 10.31917/2201033
Subject(s) - blockade , immunotherapy , pathogenesis , cancer research , medicine , tumor microenvironment , chemotherapy , mechanism (biology) , immunology , biology , oncology , bioinformatics , pharmacology , immune system , tumor cells , receptor , philosophy , epistemology
The challenging direction is the combinations of the treatment strategies affecting the various pathogenesis pathways of the malignant neoplasms. In addition to the main mechanism of action (impact on the nucleus or blockade of the cell signalling), the immunological component is included in the basis of the therapeutic effectiveness of the chemotherapy or targeted therapy. In this regard, new approaches with the checkpoint inhibitors make it possible to affect both directly the tumour cells and their microenvironment. Undoubtedly, this leads to the significant control of tumour growth and increased overall survival.