Open AccessEnzymatic synthesis of 4-methoxycinnamoylglycerol Uv filter mediated by immobilized-lipase and nanoparticle formation on N-succinylchitosan
Author(s) -
Sindy Escobar,
Claudia Bernal,
Mónica Mesa
Publication year - 2020
Publication title -
revista u.d.c.a actualidad and divulgación científica/revista udca actualidad and divulgación científica
Language(s) - English
Resource type - Journals
eISSN - 2619-2551
pISSN - 0123-4226
DOI - 10.31910/rudca.v23.n2.2020.1631
Subject(s) - lipase , chemistry , chitosan , cinnamic acid , glycerol , nanoparticle , organic chemistry , biodiesel , chromatography , enzyme , combinatorial chemistry , catalysis , materials science , nanotechnology
The synthesis of 4-methoxycinnamoylglycerol takes advantage of the biodiesel subproduct for obtaining a hydrophilic UV cinnamate derivate filter, useful in sunscreen formulations. The objective here was to demonstrate that esterification of 4-methoxycinnamic acid and glycerol mediated by immobilized-lipase from Thermomyces lanuginosus is selective towards 4-methoxycinnamoylglycerol monoester UV filter, whose chemical characteristics favor the nanoparticles formation by ionotropic gelation on N-Succinyl chitosan. A cinnamic acid conversion ~34% in hexane is higher than in other reports, without the presence of other sub-products or degradation products. This eases the purification process by liquid-liquid extraction. The free glyceryl entities favour its incorporation on N-Succinyl chitosan nanoparticles with size around 185±77nm, which are promissory for sunblock products.