Open AccessTotal body irradiation in a case of thalassemia major with source to axis distance based planning: A case report
Author(s) -
Mayuresh Virkar,
Rajkumar Chauhan,
Pranav Chadha,
Kaustav Talapatra,
Reuben Jake Rodrigues,
A.K. Shrivastava,
Santanu Sen,
Sameer Tulpule
Publication year - 2020
Publication title -
international journal of clinical and biomedical research
Language(s) - English
Resource type - Journals
eISSN - 2521-0394
pISSN - 2395-0471
DOI - 10.31878/ijcbr.2020.64.06
Subject(s) - total body irradiation , medicine , thalassemia , hematopoietic stem cell transplantation , transplantation , regimen , presentation (obstetrics) , incidence (geometry) , stem cell , surgery , chemotherapy , biology , cyclophosphamide , physics , optics , genetics
Background: The use of total body radiation (TBI) before hematopoietic stem cell transplantation (HSCT) would increase the engraftment without transplant-related morbidity or mortality among Thalassemia major (TM) cases. Case presentation: A 2-year-old female child, diagnosed with TM was scheduled for haploidentical allogenic transplant-based protocol, and after that, based on protocol she was scheduled to undergo a single session of TBI as a conditioning regimen before haploidentical allogenic hematopoietic stem cell tranplant. A total dose of 4 Gy was administered.. The incidence of graft failure was reduced as TBI was used before allogeneic stem cell transplantation. TBI provided a uniform dose of radiation to the entire body, penetrating areas such as the central nervous system (CNS) and testes. Conclusion: Total Body Irradiation with the SAD technique is the most effective way of treatment. As it is comfortable for the patient to undergo, easily reproducible, and it helps to achieve a uniform dose distribution.