Open AccessEfficiency of penetration of dopamine and serotonin peptide derivatives through the artificial membranes
Author(s) -
В. П. Шевченко,
L. A. Andreeva,
I. Yu. Nagaev,
K. V. Shevchenko,
N. F. Myasoedov
Publication year - 2019
Publication title -
doklady akademii nauk. rossijskaâ akademiâ nauk
Language(s) - English
Resource type - Journals
ISSN - 0869-5652
DOI - 10.31857/s0869-56524886682-684
Subject(s) - membrane , dopamine , peptide , penetration (warfare) , serotonin , chemistry , biophysics , chromatography , biochemistry , biology , neuroscience , mathematics , receptor , operations research
A mass spectrometric method has been developed for determining the content of dopamine and serotonin derivatives, which allows to evaluate the efficiency of their penetration through artificial membranes depending on the structure of their peptide fragment. In this case, the diffusion of dopamine and serotonin derivatives through the membrane occurred as a result of competitive interactions. It was shown which compounds in this mixture more easily penetrate through artificial membranes. It was found that the most promising in terms of overcoming the BBB are Boc-Pro-Srt and Boc-Pro-DOPA.