Open AccessAntioxidant activity of tetra nitrosyl iron complex with thiosulfate ligands and its effect on catalytic activity of mitochondrial enzymes in vitro
Author(s) -
I. I. Faingold,
R. A. Kotelnikova,
A. V. Smolina,
Д. А. Полетаева,
Yu. V. Soldatova,
O. V. Pokidova,
A. P. Sadkov,
N. A. Sanina,
S. M. Aldoshin
Publication year - 2019
Publication title -
doklady akademii nauk. rossijskaâ akademiâ nauk
Language(s) - English
Resource type - Journals
ISSN - 0869-5652
DOI - 10.31857/s0869-56524885571-575
Subject(s) - monoamine oxidase , chemistry , antioxidant , in vitro , thiosulfate , enzyme , biochemistry , mitochondrion , cytochrome c oxidase , catalysis , organic chemistry , sulfur
The antioxidant and antiradical properties of the tetra nitrosyl iron complex with thiosulfate ligands (TNIC) in the mouse brain homogenates in vitro were also studied. It was found for the first time that TNIC is an effective antioxidant. The effect of TNIC on the catalytic activity of mitochondrial enzymes: cytochrome c oxidase and monoamine oxidase A has been studied. It was shown for the first time that TNIC is an inhibitor of the catalytic activity of cytochrome c oxidase and monoamine oxidase A in the brain mitochondria isolated from animals in vitro.