Open AccessThe novel element in the mechanism of endogenous regulation of depressive-like states
Author(s) -
Т. Л. Гарибова,
Т. Л. Гарибова,
Т. А. Gudasheva,
Т. А. Гудашева,
С. Б. Середенин,
S. B. Seredenin
Publication year - 2019
Publication title -
doklady akademii nauk. rossijskaâ akademiâ nauk
Language(s) - English
Resource type - Journals
ISSN - 0869-5652
DOI - 10.31857/s0869-56524884443-445
Subject(s) - learned helplessness , endogeny , ampa receptor , antidepressant , neuropeptide , medicine , neuroscience , endocrinology , mechanism (biology) , receptor , pharmacology , chemistry , hippocampus , psychology , glutamate receptor , developmental psychology , physics , quantum mechanics
It was shown previously that cyclo-prolylglycine, an endogenous neuropeptide, is a positive AMPA receptor modulator and is able to increase the content of BDNF in neurons. In the present work it was shown that cyclo-prolylglycine at a dose of 1 mg/kg with subchronic intraperitoneal administration reduces the time of animal immobility to passive control, from 167.6 to 83.6 s on the 12th day of the experiment using the model of learned helplessness in rats. That indicates the presence of antidepressant-like activity. The results of the study allow us to consider that cyclo-prolylglycine is a link in the physiological regulation of a depressive-like state.