Open AccessPotassium salt of fullerenylpenta-N-dihydroxytyrosine effects on type 2 diabetes mellitus therapeutic targets
Author(s) -
Yu. V. Soldatova,
R. A. Kotelnikova,
Alexander V. Zhilenkov,
I. I. Faingold,
Pavel A. Troshin,
Maria Kozlova,
David А. Areshidze,
С. М. Алдошин
Publication year - 2019
Publication title -
doklady akademii nauk. rossijskaâ akademiâ nauk
Language(s) - English
Resource type - Journals
ISSN - 0869-5652
DOI - 10.31857/s0869-56524883338-341
Subject(s) - aldose reductase , sorbitol , sorbitol dehydrogenase , salt (chemistry) , potassium , chemistry , bovine serum albumin , enzyme , medicine , dehydrogenase , diabetes mellitus , type 2 diabetes mellitus , biochemistry , endocrinology , organic chemistry
It was shown for the first time that pentaamino acid derivative of fullerene C60 (potassium salt of fullerenylpenta-N-dihydroxytyrosine) effects on three targets of type 2 diabetes mellitus. It competitively inhibits the enzymes aldose reductase and sorbitol dehydrogenase and also exhibits antiglycation effect on bovine serum albumin. The enzymes inhibition constants were calculated.