Open AccessEffect of fabomotizole on brain gene expression in MR rats upon open field test
Author(s) -
Yu. V. Vakhitova,
U. Sh. Kuzmina,
M. V. Voronin,
Л. Ф. Зайнуллина,
S. B. Seredenin
Publication year - 2019
Publication title -
doklady akademii nauk. rossijskaâ akademiâ nauk
Language(s) - English
Resource type - Journals
ISSN - 0869-5652
DOI - 10.31857/s0869-56524883329-332
Subject(s) - translation (biology) , open field , gene expression , receptor , anxiolytic , neuroscience , chemistry , microbiology and biotechnology , pharmacology , biology , gene , messenger rna , endocrinology , biochemistry
Selective anxiolytic fabomotisol (Afobazol®) has affinity for the Sigma-1 chaperone receptor site, quinone reductase 2 (NQO2) and MAO-A regulatory sites, and melatonin receptor type 1 (MT1 receptor). The analysis of the effect of fabomotisol on the gene expression profile in the brain of MR (Maudsley Reactive) rats was carried out when modeling emotional stress in the open field test. A change in the expression of 14 genes was found, the results of the functional annotation of which show that the mechanisms of action of fabomotisol may be associated with the regulation of translation of proteins (Rpl5, Rpl15, Ncl, Ybx1), synaptic functions (Cplx2, Dlg4, Syngap1, Add1, Rab8b, Klc1, Chn1) and cellular metabolism (Akr1d1, Bcat1, Pkm).