Open AccessSigma-1 receptor agonist amitriptyline inhibits store-dependent Ca2+ entry in macrophages
Author(s) -
Z. I. Krutetskaya,
L. S. Milenina,
В. Г. Антонов,
А. Д. Ноздрачев
Publication year - 2019
Publication title -
doklady akademii nauk. rossijskaâ akademiâ nauk
Language(s) - English
Resource type - Journals
ISSN - 0869-5652
DOI - 10.31857/s0869-56524882221-224
Subject(s) - cyclopiazonic acid , thapsigargin , amitriptyline , agonist , sigma receptor , sigma 1 receptor , chemistry , pharmacology , receptor , endoplasmic reticulum , microbiology and biotechnology , endocrinology , biochemistry , biology
Using Fura-2AM microfluorimetry we have shown for the first time that sigma-1 receptor agonist - tricyclic antidepressant amitriptyline - significantly inhibits store-dependent Ca2+ entry, induced by endoplasmic Ca2+-ATPase inhibitors thapsigargin and cyclopiazonic acid, in rat peritoneal macrophages. The results suggest possible involvement of sigma-1 receptors in the regulation of store-dependent Ca2+ entry in macrophages.