Open AccessCombined irradiation by gamma rays and carbon nuclei increases the C/EBP-β LIP-isoform content in the pituitary gland of rats
Author(s) -
I. P. Anokhina,
П. К. Анохин,
В. С. Кохан
Publication year - 2019
Publication title -
doklady akademii nauk. rossijskaâ akademiâ nauk
Language(s) - English
Resource type - Journals
ISSN - 0869-5652
DOI - 10.31857/s0869-56524881108-111
Subject(s) - gene isoform , ionizing radiation , medicine , pituitary gland , endocrinology , immune system , apoptosis , endoplasmic reticulum , biology , irradiation , chemistry , microbiology and biotechnology , gene , immunology , biochemistry , hormone , physics , nuclear physics
C/EBP-β, a basic leucine zipper transcription factor, has important roles in the regulation of organism’s immune and inflammatory responses. Wistar rats subjected to the combined irradiation were characterized by an increase in the content of C/EBP-β LIP-isoform in the pituitary gland. The obtained data indicate that moderate doses of ionizing radiation to initiate the endoplasmic reticulum stress response and are likely to initiate C/EBP-β-mediated cell death according to the apoptotic scenario. This study also confirms the earlier hypothesis about the alterations of the hypothalamic-pituitary-adrenocortical axis in response to moderate doses of ionizing radiation.