Open AccessChanges in the regulatory T-lymphocyte counts in HIV-infected patients with a discordant response to antiretroviral therapy
Author(s) -
Е. В. Сайдакова,
K. V. Shmagel,
N. G. Shmagel,
L. B. Korolevskaya,
В. А. Черешнев
Publication year - 2019
Publication title -
doklady akademii nauk. rossijskaâ akademiâ nauk
Language(s) - English
Resource type - Journals
ISSN - 0869-5652
DOI - 10.31857/s0869-56524875584-587
Subject(s) - immunology , immune system , antiretroviral therapy , human immunodeficiency virus (hiv) , regulatory t cell , medicine , t cell , t lymphocyte , immunodeficiency , lymphocyte , immunopathology , virology , biology , viral load , il 2 receptor
We examined HIV‑infected patients with different efficiency of immune system restoration during the course of antiretroviral therapy. The study showed that against the background of low CD4+ T‑cell counts, subject with a discordant immunologic response (patients with less than 350 CD4+ T‑cells per µl of blood after more than two years of treatment) develop a regulatory CD4+ T‑cell (Treg) deficiency. Furthermore, in these patients, the immunodeficiency is accompanied by an increase in the Treg frequency. Accumulation of regulatory T‑cells in the blood of HIV‑infected subjects with discordant response to the treatment indicates a high viability of this T‑cell subset.