Open AccessEncapsulation of neurotoxins - blockers of nicotinic acetylcholine receptors - in nanomaterials based on sulfated polysaccharides
Author(s) -
Trung Dinh Nguyen,
The N. Nguyen,
Khoa Cuu Nguyen,
Quyen Ngoc Tran,
Anh Hoang,
N. S. Egorova,
Vladislav G. Starkov,
V. I. Tsetlin,
Yuri N. Utkin
Publication year - 2019
Publication title -
doklady akademii nauk. rossijskaâ akademiâ nauk
Language(s) - English
Resource type - Journals
ISSN - 0869-5652
DOI - 10.31857/s0869-56524871102-106
Subject(s) - neurotoxin , chemistry , receptor , nicotinic agonist , acetylcholine , acetylcholine receptor , cholinergic , nanomaterials , nicotinic acetylcholine receptor , pharmacology , biophysics , biochemistry , biology , nanotechnology , neuroscience , materials science
The three-finger snake neurotoxins are selective antagonists of some nicotinic cholinergic receptor subtypes and are used to study these receptors. The peptide neurotoxin azemiopsin, recently isolated from the venom of Azemipos feae, is a selective muscle-type cholinergic receptor blocker. In order to reduce their toxicity and increase resistance under physiological conditions, we have encapsulated these toxins into nanomaterials. The study of nanomaterials after interaction with neurotoxins by the methods of transmission electron microscopy and dynamic light scattering revealed an increase in the size of nanoparticles, which indicates the inclusion of neurotoxins in nanomaterials.