Open AccessReactivity of 2-nitroxysuccinate 3-hydroxy-6-methyl-2-ethylpyridine and reference drugs in model NO-generating systems
Author(s) -
O. V. Pokidova,
O. V. Pokidova,
E. V. Batova,
E. V. Batova,
A. P. Sadkov,
A. P. Sadkov,
A. B. Eremeev,
A. B. Eremeev,
Б. С. Федоров,
Б. С. Федоров,
А. И. Котельников,
А. И. Котельников
Publication year - 2019
Publication title -
doklady akademii nauk. rossijskaâ akademiâ nauk
Language(s) - English
Resource type - Journals
ISSN - 0869-5652
DOI - 10.31857/s0869-56524864437-440
Subject(s) - chemistry , reactivity (psychology) , nitrite , medicinal chemistry , cysteine , nitrogen , organic chemistry , nitrate , medicine , alternative medicine , pathology , enzyme
The ability of the 2-nitroxysuccinate 3-hydroxy-6-methyl-2-ethylpyridine (I) compound to generate nitrite ions (NO2) and nitrogen monoxide (NO) in model systems with cysteine (Cys) and deoxyhemoglobin (Hb) has been studied. It has been established that there is a more efficient release NO2 and NO from compound I than from Nicorandil. The accumulation rate is 1.5 times higher in the system of Cys with I than with Nitroglycerin. It is shown that, unlike Nitroglycerin, compound I is not reduced by Hb.