Open AccessNeuroprotective action of amidic neurolipins in models of neurotoxicity on the culture of human neural-like cells SH-SY5Y
Author(s) -
Mikhail Akimov,
А. М. Ашба,
E. V. Fomina-Ageeva,
N. M. Gretskaya,
N. F. Myasoedov,
В. В. Безуглов
Publication year - 2019
Publication title -
doklady akademii nauk. rossijskaâ akademiâ nauk
Language(s) - English
Resource type - Journals
ISSN - 0869-5652
DOI - 10.31857/s0869-56524855625-628
Subject(s) - sh sy5y , neuroprotection , neurotoxicity , neurodegeneration , chemistry , amide , cell culture , biochemistry , pharmacology , biology , toxicity , neuroblastoma , medicine , organic chemistry , genetics , disease
It was established that in neurodegeneration models in the human neuron-like cell line SH-SY5Y, amide derivatives of arachidonic and docosahexaenoic acids were inactive in experiments with MPP+ and CoCl2 but protected from H2O2. The protective activity of neurolipins decreased in the series DHA-DA > AA-SER >= AA-GLY > AA-GABA >= AA-EA and was manifested starting from a concentration of 0.5 nM.