Open AccessThe steroidogenic effect of a low-molecular agonist of luteinizing hormone receptor in the course of its administration to male rats
Author(s) -
A. A. Bakhtyukov,
К. В. Деркач,
Dmitry Dar’in,
А. О. Шпаков
Publication year - 2019
Publication title -
doklady akademii nauk. rossijskaâ akademiâ nauk
Language(s) - English
Resource type - Journals
ISSN - 0869-5652
DOI - 10.31857/s0869-56524846760-763
Subject(s) - medicine , endocrinology , human chorionic gonadotropin , agonist , cholesterol side chain cleavage enzyme , luteinizing hormone , testosterone (patch) , steroidogenic factor 1 , hormone , receptor , leydig cell , biology , cytochrome p450 , gene , nuclear receptor , metabolism , biochemistry , transcription factor
The thienopyrimidine derivative TP03 (a low molecular weight agonist of the luteinizing hormone receptor, LHR), when administered to male Wistar rats, stimulated the production of testosterone (“T”), elevated level of which was maintained for 7 days, and increased the expression of the LHR gene. At the same time, the steroidogenic effect of human chorionic gonadotropin (hCG), which significantly increased the “T” level on the first day of treatment, was further weakened, which was accompanied by a decrease in the expression of the LHR gene in the testes, indicating the development of resistance of Leydig cells to hCG. In the testes, the hCG treatment induced a compensatory increase in the expression of genes of the steroidogenic enzymes, such as the cytochrome P450scc and the dehydrogenase 3P-HSD. In the case of TP03 treatment this effect was absent.