Open AccessRegulation of recombinase RAG-1 expression by female sex steroids in Treg and Th17 lymphocytes. role of oncostatin M
Author(s) -
С. В. Ширшев,
И. В. Некрасова,
О. Л. Горбунова,
Е. Г. Орлова
Publication year - 2019
Publication title -
doklady akademii nauk. rossijskaâ akademiâ nauk
Language(s) - English
Resource type - Journals
ISSN - 0869-5652
DOI - 10.31857/s0869-56524845641-644
Subject(s) - oncostatin m , rar related orphan receptor gamma , treg cell , immune system , cre recombinase , biology , endocrinology , medicine , microbiology and biotechnology , chemistry , t cell , transgene , immunology , il 2 receptor , interleukin 6 , genetically modified mouse , inflammation , genetics , gene , foxp3
The effect of estradiol (E2), progesterone (P4), and oncostatin M (OSM) on the differentiation of CD4+ T cells to T regulatory (Treg) lymphocytes and T helpers 17 (Th17) was investigated. The possibility of revision of the T cell receptor in these subpopulations by evaluating the expression of RAG-1 recombinase was also studied. E2 at concentrations characteristic of pregnancy trimester I, but no P4 or OSM, increased the Treg level. Combination of sex steroids with OSM increased the percent of CD4+FOXP4+ cells and enhanced RAG-1 expression in these cells, thus promoting the development of immune tolerance during pregnancy. In the study of Th17 such effect of the hormones and OSM was not detected.