Open AccessExperience of the application of antiseptics for the treatment of biological matrixes of rat lung
Author(s) -
Е. В. Куевда,
Е. В. Куевда,
Е. А. Губарева,
Е. А. Губарева,
А. А. Басов,
А. А. Басов,
S. V. Krasheninnikov,
Sergey V. Krasheninnikov,
T. E. Grigoriev,
Т. Е. Григорьев,
I. S. Gumenyuk,
И. С. Гуменюк,
С. С. Джимак,
С. С. Джимак,
О. А. Качанова,
О. А. Качанова,
С. Н. Чвалун,
С. Н. Чвалун
Publication year - 2019
Publication title -
doklady akademii nauk. rossijskaâ akademiâ nauk
Language(s) - English
Resource type - Journals
ISSN - 0869-5652
DOI - 10.31857/s0869-56524844498-502
Subject(s) - decellularization , chlorhexidine , extracellular matrix , matrix (chemical analysis) , biomedical engineering , antiseptic , chemistry , human decontamination , chemiluminescence , dentistry , chromatography , medicine , pathology , biochemistry , organic chemistry
In order to select the optimal method for disinfecting the scaffolds prior to decellularization using morphological methods (studying the biomechanical strength of extracellular matrix fibers) and analyzing chemiluminescence in rats, the effect of octenisept and chlorhexidine was studied at different concentrations on the biological matrices of the lungs before and after decellularization. Chlorhexidine at a dilution of 1:10 possessed the least damaging properties for the matrix and most contributed to the decontamination of the cages for further storage and experimental studies.