Open AccessBiotechnological method of preparation and characterization of recombinant antimicrobial peptide avicin a from Enterococcus avium
Author(s) -
S. V. Balandin,
E. I. Finkina,
E. K.-A. Nurmukhamedova,
A. A. Tagaev,
Ekaterina S. Umnyakova,
V. N. Kokryakov,
V. I. Shvets,
T. V. Ovchinnikova
Publication year - 2019
Publication title -
doklady akademii nauk. rossijskaâ akademiâ nauk
Language(s) - English
Resource type - Journals
ISSN - 0869-5652
DOI - 10.31857/s0869-56524844491-494
Subject(s) - antimicrobial , bacteriocin , microbiology and biotechnology , enterococcus , bacteria , listeria , antimicrobial peptides , recombinant dna , biology , listeria monocytogenes , peptide , antibiotics , biochemistry , genetics , gene
Avicin A is a bacteriocin from the gram-positive bacterium Enterococcus avium. It exhibits a high microbicidal activity against bacteria of the genus Listeria, a causative agent of the severe human infection listeriosis. We developed a biotechnological method for obtaining avicin A and characterized its structure and biological activity. We also proposed a possible mechanism of the antimicrobial action of avicin A.