Open AccessDynamics of intravital concentration of amino acid metabolites in human brain in post-traumatic period
Author(s) -
Н. А. Семенова,
Н. А. Семенова,
Petr Menshchikov,
Petr Menshchikov,
А. В. Манжурцев,
А. В. Манжурцев,
M. V. Ublinskiy,
М. В. Ублинский,
Т. А. Ахадов,
Т. А. Ахадов,
S. D. Varfolomeev,
S. D. Varfolomeev
Publication year - 2019
Publication title -
doklady akademii nauk. rossijskaâ akademiâ nauk
Language(s) - English
Resource type - Journals
ISSN - 0869-5652
DOI - 10.31857/s0869-56524842238-242
Subject(s) - glutamate receptor , traumatic brain injury , period (music) , chemistry , amino acid , medicine , endocrinology , intracellular , human brain , biochemistry , biology , neuroscience , acoustics , physics , receptor , psychiatry
Intracellular concentrations of N acetyaspartate (NAA), aspartate (Asp) and glutamate (Glu) were determined for the first time in human brain in vivo, and the effect of severe traumatic brain injury on NAA synthesis in acute and late post-traumatic period was investigated. In MRI‑negative frontal lobes one day after injury Asp and Glu levels were found to decrease by 45 and 35%, respectively, while NAA level decreased by only 16%. A negative correlation between NAA concentration and the ratio of Asp/Glu concentrations was found. In the long-term period, Glu level returned to normal, Asp level remained below normal by 60%, NAA level was reduced by 65% relative to normal, and Asp/Glu ratio significantly decreased. The obtained results revealed leading role of the neuronal aspartate-malate shuttle in violation of NAA synthesis.