
SUBCHRONIC TOXICITY OF MICROENCAPSULATED PROBIOTIC DRUG “ENZYMSPORINE WITH TRYPSIN” AND ITS APPLICATION IN PIG PRODUCTION
Publication year - 2021
Publication title -
journal of critical reviews
Language(s) - English
Resource type - Journals
ISSN - 2394-5125
DOI - 10.31838/jcr.07.09.326
Subject(s) - probiotic , drug , toxicity , microbiology and biotechnology , pharmacology , veterinary drug , medicine , biology , chemistry , genetics , chromatography , bacteria
The rationale for the study is explained by the fact that regular application of probiotic feeding supplements in pigbreeding positively influences the growth and development of young stock, in particular, increases mean daily weightgain, normalizes the performance of the gastrointestinal tract and enforces the resistance of the organism. For this reason, a microencapsulated probiotic drug ―Enzymsporine withtrypsin‖ was developed in the facilities of Kursk StateAgricultural Academy (Kursk, Russia). The authors studied the drug’s biological safety. The main method of the studyof biological safety of the drug was the study of its subchronic toxicity that would allow for the production trials of thisdrug on agricultural animals. The article presents the experimental data obtained during the tests on Wistar rats.Thetests on rats showed that new encapsulated probiotic drug ―Enzymsporine with trypsin‖ was safe in the doses that exceeded the recommended for the application in animal farming by 2 and 10 times. This provided perspectives for theapplication of this drug in animal production for the optimization of metabolism, an increase in the mass of animals, andthe safety of meat products for humans.