Open AccessIs it True that the Corona Virus will take a Few Years to Get Completely Eradicated?
Author(s) -
Shimon Shatzmiller,
Rami Galinaszats,
Ingeborg Krieger
Publication year - 2020
Publication title -
archives of health science
Language(s) - English
Resource type - Journals
ISSN - 2641-7456
DOI - 10.31829/2641-7456/ahs2020-4(1)-149
Subject(s) - medicine , disease , immune system , immunology , asymptomatic , covid-19 , clinical trial , protease , bioinformatics , monoclonal antibody , intensive care medicine , pharmacology , antibody , biology , infectious disease (medical specialty) , biochemistry , enzyme
Lots of hope but also illusions. It all depends on the future vaccine [1]that will allow human protection against the Corona (COVID 19) disease. The disease caused by SARS-CoV-2, termed COVID-19, is multifactorial and associated with both specific antiviral as well as inflammatory responses, the extent of which may determine why some individuals are asymptomatic while others develop serious complications. Here we review possible life-threatening immune events that may occur during disease progression to uncover key factors behind COVID-19 severity and provide suggestions for interventions with repurposed drugs in well-controlled and randomized clinical trials. These drugs include therapeutics with potential to inhibit SARS-CoV-2 entry into host cells such as serine protease inhibitors of the TMPS2 cellular protease and drugs targeting the renin-angiotensin system; antivirals with potential to block SARS-CoV-2 replication or factors that could boost the antiviral response; monoclonal antibodies targeting pro-inflammatory cytokines that drive the hyper inflammatory response during COVID-19 progression toward the severe stage and therapeutics that could ameliorate the function of the lungs. Furthermore, in order to help make more informed decisions on the timing of the intervention with the drugs listed in this review, we have grouped these therapeutics according to the stage of COVID-19 progression that we considered most appropriate for their mechanism of action.[2]