Open AccessSYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF 4-THIAZOLIDINONE AND ITS DERIVATIVES BASED ON ISONIAZID
Author(s) -
Hiteshkumar Gujjar,
Sheetal Gulati,
H. S. Patel,
Hitesh Samata
Publication year - 2022
Publication title -
rasayan journal of chemistry/rasayan journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.281
H-Index - 22
eISSN - 0976-0083
pISSN - 0974-1496
DOI - 10.31788/rjc.2022.1516803
Subject(s) - mannich base , isoniazid , chemistry , formaldehyde , acetic acid , yield (engineering) , antimicrobial , schiff base , amine gas treating , proton nmr , organic chemistry , mannich reaction , base (topology) , antibacterial activity , elemental analysis , nuclear chemistry , combinatorial chemistry , stereochemistry , bacteria , tuberculosis , mathematics , materials science , catalysis , medicine , mathematical analysis , pathology , biology , metallurgy , genetics
The Schiff bases of (1a-e) isoniazid and 5-substituted- 2-furancarboxaldehydes on treatment with mercapto acetic acid yield, 4-thiazolidinone (2a-e) derivatives. These derivatives (2a-e) on Mannich base reaction with diphenyl amine and formaldehyde yielded the Mannich base products (3a-e). All the derivatives, (2a-e) and (3a-e) were characterized by elemental content and IR , NMR, LC-MS spectral data. All the derivatives have also been monitored for antibacterial activity.