SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF PYRAZOLE-PYRIMIDONE CLUBBED DERIVATIVES | Zendy

Nikulsinh Sarvaiya | Zendy; Hitesh Samata | Zendy; Sheetal Gulati | Zendy; Harish Patel | Zendy

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SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF PYRAZOLE-PYRIMIDONE CLUBBED DERIVATIVES

Author(s) -

Nikulsinh Sarvaiya,

Hitesh Samata,

Sheetal Gulati,

Harish Patel

Publication year - 2022

Publication title -

rasayan journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.281

H-Index - 22

eISSN - 0976-0083

pISSN - 0974-1496

DOI - 10.31788/rjc.2022.1516656

Subject(s) - benzene , antimicrobial , chemistry , pyrazole , aryl , furan , medicinal chemistry , condensation , organic chemistry , alkyl , physics , thermodynamics

4-(2-(1-(4-aryl-3-(furan-2-yl(hydroxy)methyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl)-3-methyl5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-N-(thiazol-2-yl) benzene sulphonamides (2a-e) were synthesised by condensation of 4-(2-(1-(4-aryl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl)-3-methyl-5-oxo-1Hpyrazol-4(5H)-ylidene) hydrazinyl)-N-(thiazol-2-yl) benzene sulphonamide (1a-e) with furfuraldehyde. The structures of all the compounds (2a-e) were characterized duly. The compounds were also monitored for antimicrobial activity.

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