Open AccessSYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF PYRAZOLE-PYRIMIDONE CLUBBED DERIVATIVES
Author(s) -
Nikulsinh Sarvaiya,
Hitesh Samata,
Sheetal Gulati,
Himatkumar V. Patel
Publication year - 2022
Publication title -
rasayan journal of chemistry/rasayan journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.281
H-Index - 22
eISSN - 0976-0083
pISSN - 0974-1496
DOI - 10.31788/rjc.2022.1516656
Subject(s) - benzene , antimicrobial , chemistry , pyrazole , aryl , furan , medicinal chemistry , condensation , organic chemistry , alkyl , physics , thermodynamics
4-(2-(1-(4-aryl-3-(furan-2-yl(hydroxy)methyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl)-3-methyl5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-N-(thiazol-2-yl) benzene sulphonamides (2a-e) were synthesised by condensation of 4-(2-(1-(4-aryl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl)-3-methyl-5-oxo-1Hpyrazol-4(5H)-ylidene) hydrazinyl)-N-(thiazol-2-yl) benzene sulphonamide (1a-e) with furfuraldehyde. The structures of all the compounds (2a-e) were characterized duly. The compounds were also monitored for antimicrobial activity.