Open AccessMICROWAVE ASSISTED ONE-POT THREE-COMPONENT SYNTHESIS OF 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES USING SFHS AS AN EFFICIENT AND REUSABLE CATALYST
Author(s) -
A.S. Waghmare,
K.R. Kadam,
V.D. Murade,
S.S. Pandit
Publication year - 2022
Publication title -
rasayan journal of chemistry/rasayan journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.281
H-Index - 22
eISSN - 0976-0083
pISSN - 0974-1496
DOI - 10.31788/rjc.2022.1516634
Subject(s) - catalysis , thiourea , aldehyde , chemistry , urea , biginelli reaction , condensation , one pot synthesis , hydrogen sulfate , organic chemistry , condensation reaction , combinatorial chemistry , component (thermodynamics) , ionic liquid , physics , thermodynamics
A simple and efficient one-pot three-component microwave assisted syntheses of 3,4-dihydropyrimidin-2(1H)- ones/thione derivatives were carried out by condensation of ethylacetoacetate/ methylacetoacetate, aromatic aldehydes and urea/thiourea by using silica ferric hydrogen sulfate as a reusable catalyst.It has been observed that a small amount of SFHS (5 mol%) is sufficient to bring out the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones. Structurally diversed aromatic aldehyde bearing electron donating, withdrawing groups and hetero-atom were reacted smoothly used under the same reaction condition.High yields, shorter reaction times, one pot condensation, operational simplicity, easy work-up, and purification of products by non-chromatographic methods are some additional features of this method.Furthermore, the catalyst can be recovered and reused five times without any significant loss of activity.