Open AccessA NEW MICROWAVE-ASSISTED METHOD FOR THE SYNTHESIS OF 2-SUBSTITUTED-THIAZOL-4(5H)-ONE VIA HANTZSCH CONDENSATION
Author(s) -
Swarnagowri Nayak,
Santosh L. Gaonkar
Publication year - 2022
Publication title -
rasayan journal of chemistry/rasayan journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.281
H-Index - 22
eISSN - 0976-0083
pISSN - 0974-1496
DOI - 10.31788/rjc.2022.1516578
Subject(s) - condensation , yield (engineering) , microwave , fourier transform infrared spectroscopy , carbon 13 nmr , chemistry , combinatorial chemistry , proton nmr , condensation reaction , catalysis , materials science , organic chemistry , chemical engineering , computer science , thermodynamics , physics , metallurgy , telecommunications , engineering
A new microwave-assisted method is developed for the synthesis of 2-substituted-thiazol-4(5H)-ones via Hantzsch condensation by a simple experimental protocol without using any catalyst. The products were isolated in excellent yield without any purification. Synthesized compounds were characterized by applying FTIR, 1H NMR, 13C NMR, and mass spectral studies and a plausible mechanism is proposed for the formation of the product. The method is versatile for the preparation of a new class of 2-substituted-thiazol-4(5H)-ones.