Open AccessSYNTHESIS, DOCKING AND BIOLOGICAL EVALUATION OF 3-(3-CHLOROBENZOYL)-N-PHENYLINDOLIZINE-1- CARBOXAMIDE DERIVATIVES AS ANTI-TUBERCULOSIS, ANTICANCER, ANTI-INFLAMMATORY AND ANTIBACTERIAL AGENTS
Author(s) -
G. Mahanthesha,
T. Suresh,
T. R. Ravikumar Naik
Publication year - 2022
Publication title -
rasayan journal of chemistry/rasayan journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.281
H-Index - 22
eISSN - 0976-0083
pISSN - 0974-1496
DOI - 10.31788/rjc.2022.1516577
Subject(s) - chemistry , triethylamine , in vitro , docking (animal) , carboxamide , antibacterial activity , proton nmr , carbon 13 nmr , stereochemistry , reagent , combinatorial chemistry , organic chemistry , biochemistry , bacteria , biology , medicine , nursing , genetics
A series of substituted 3-(3-chlorobenzoyl)-N-phenylindolizine-1-carboxamides have been synthesized from 3- chlorobenzoyl-indolizine-1-carboxylic acid with substituted aromatic amines in the presence of triethylamine and Pybop reagent. All the newly synthesized compounds were confirmed by Elemental, FTIR, 1H NMR, 13C NMR and Mass spectroscopic techniques. The obtained target compounds showed excellent in vitro anti-tuberculosis, anticancer, anti-inflammatory and antibacterial activity. Molecular docking studies have supported the in vitro anticancer activity of these molecules.