Open AccessANTIPLASMODIAL ACTIVITY AND MALATE QUINONE OXIDOREDUCTASE INHIBITOR OF STEROID ISOLATED FROM Fibraurea tinctoria
Author(s) -
Riski Sulistiarini,
Andreanus Andaja Soemardji,
Elfahmi Elfahmi,
Maria Immaculata Iwo,
Dian Japany Puspitasari,
Erwahyuni Endang Prabandari,
Danang Waluyo
Publication year - 2022
Publication title -
rasayan journal of chemistry/rasayan journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.281
H-Index - 22
eISSN - 0976-0083
pISSN - 0974-1496
DOI - 10.31788/rjc.2022.1516096
Subject(s) - plasmodium falciparum , oxidoreductase , chemistry , biochemistry , lactate dehydrogenase , traditional medicine , enzyme , malaria , pharmacology , biology , medicine , immunology
Malaria is an infectious disease that causes 400,000 deaths every year. Based on that fact, antimalarial exploration needs to be developed. This study aimed to explore another compound in Fibraurea tinctoria that is known to have antiplasmodial activity from the berberine compound. Lactate dehydrogenase (LDH) assay and malate quinone oxidoreductase (pfMQO) inhibitor assay against Plasmodium falciparum 3D7 was used to evaluate the activity. The result showed that methanol extract, n-hexane fraction, n-hexane subfraction, and steroid compounds isolated from nhexane subfraction had the potential ability to inhibit the growth of Plasmodium falciparum 3D7 as well as the pfMQO enzyme. The results indicate that Fibraurea tinctoria may serve as a promising medicinal plant for future antimalarial drug development.