Open AccessGASTRIC ADENOCARCINOMA AND HELICOBACTER PYLORI INFECTION
Author(s) -
Ram Chandra Adhikari,
Bharat Pokharel,
Hemant Shrestha
Publication year - 2003
Publication title -
journal of nepal medical association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.176
H-Index - 19
eISSN - 1815-672X
pISSN - 0028-2715
DOI - 10.31729/jnma.681
Subject(s) - medicine , helicobacter pylori , giemsa stain , gastroenterology , adenocarcinoma , serology , cancer , spirillaceae , pathology , gastritis , antibody , immunology
Gastric adenocarcinoma is of major importance worldwide as a cause of death frommalignant disease. It is the commonest malignant tumor in T.U. Teaching Hospital.Helicobacter pylori infection is an important risk factor for the development of gastriccancer. This prospective study was carried out to correlate H. pylori infection withgastric adenocarcinoma. This study was done from January 1999 to January 2000;included 38 cases of gastric adenocarcinomas of which 28 (73.69%) cases were tubulartype; 6 (15.79%) cases were signet-ring cell type; 2 (5.26%) cases were papillary typeand 2 (5.26%) cases were mucinous type. Gastric adenocarcinomas were more commonin male (73.68%) and after the age of 50 years. Giemsa staining revealed H. pylori in30 cases (78.95%) of adenocarcinomas; whereas H. pylori seropositivity (IgG) wasfound in 29 (76.31%) cases. H. pylori were histologically detected in 88.3% cases ofresected specimens and in 71.4% cases of endoscopic gastric biopsies. Both histologicalmethod and serological test showed positivity for H. pylori in 65.78% cases. Thus, H.pylori infection is associated with gastric carcinognesisKey Words: Gastric adenocarcinoma, Helicobacter pylori, Giemsa stain.