Open AccessPralidoxime in organophosphorus poisoning
Author(s) -
Naba Raj Simkhada,
Kumud Kumar Kafle,
PN Prasad
Publication year - 2010
Publication title -
journal of nepal medical association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.176
H-Index - 19
eISSN - 1815-672X
pISSN - 0028-2715
DOI - 10.31729/jnma.62
Subject(s) - pralidoxime , medicine , cholinesterase , toxicology , acetylcholinesterase , intensive care medicine , pharmacology , enzyme , biochemistry , chemistry , biology
INTRODUCTION:
Pralidoxime are enzyme reactivator that are known to reactivate the phosphorylated acetylcholinesterase by binding to the organophosphorus molecule. The use of oximes in acute organophosphorus poisoning has been a controversial subjects for over two decades. This study was conducted with the objective to find out the estimation of serum cholinesterase and use of pralidoxime in organophosphorus poisoning.
METHODS:
A prospective analysis of all organophosphorus poisoning cases presented at the Emergency Department, Tribhuvan University Teaching Hospital for seven months was done.
RESULTS:
Out of 26 cases about 60% of poisoning cases were monitored for pseudocholinesterase level. About 50% of them had pseudocholinesterase level within normal limit and 20% had less than 10% of normal value. Only 33% cases with pseudocholinesterase level less than 10% were treated with pralidoxime.
CONCLUSIONS:
The initial dose of Pralidoxime used was 1 gm followed by maintenance dose of 500mg 6 hourly, the doses prescribed were less than WHO recommended doses.
Keywords: cholinesterase, emergency, organophosphorus,poisoning, Pralidoxime.