Open AccessHerlyn Werner Wunderlich Syndrome Presenting with Ischemic Stroke due to Suspected Paroxysmal Nocturnal Hemoglobinuria: A Case Report
Author(s) -
Ayushma Acharya,
Prajwala Yogi,
Pramod Singh,
Tulsi Ram Bhattarai
Publication year - 2021
Publication title -
journal of nepal medical association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.176
H-Index - 19
eISSN - 1815-672X
pISSN - 0028-2715
DOI - 10.31729/jnma.5838
Subject(s) - paroxysmal nocturnal hemoglobinuria , medicine , pancytopenia , hemoglobinuria , eculizumab , pediatrics , stroke (engine) , bone marrow failure , bone marrow , anemia , cardiology , surgery , immunology , mechanical engineering , antibody , complement system , engineering , genetics , stem cell , haematopoiesis , biology
Paroxysmal nocturnal hemoglobinuria can rarely present as cerebral ischemia and stroke due to arterial thrombosis. However, it should be considered in a young patient with bone marrow failure features, systemic thromboses, and hemolysis. The variants of paroxysmal nocturnal hemoglobinuria pose a diagnostic challenge and hence are important to recognize. We report a case of a 28-years-old female with Herlyn Werner Wunderlich Syndrome who presented with an ischemic cerebrovascular accident, pancytopenia, hemoglobinuria, and widespread abdominal thromboses suggestive of paroxysmal nocturnal hemoglobinuria. The patient was managed symptomatically and referred to a hematologist.