Open AccessFORENSIC-MEDICINE DETERMINATION OF ASPHICTIC STATE BY QUALITATIVE AND QUANTITATIVE INDICATORS OF TROPONIN I
Author(s) -
O. E. Volobuiev
Publication year - 2021
Publication title -
aktualʹnì problemi sučasnoï medicini: vìsnik ukraïnsʹkoï medičnoï stomatologìčnoï akademì
Language(s) - English
Resource type - Journals
eISSN - 2077-1126
pISSN - 2077-1096
DOI - 10.31718/2077-1096.21.4.135
Subject(s) - asphyxia , medicine , troponin , cardiology , cause of death , disease , anesthesia , myocardial infarction
The aim of the work was to determine the qualitative and quantitative content of the biochemical marker of myocardial damage (Troponin I) in the blood as a diagnostic criterion for asphyxia in cases of death from mechanical asphyxia. Material and methods of research. To determine the presence of an asphyxia, the indicators of the qualitative and quantitative content of Troponin I in the blood of 15 deceased were studied and analyzed, among which violent death was observed in 9 cases and non-violent in 6 cases. During the study, rapid tests were used for the qualitative detection of Troponin I; To determine the quantitative content of troponin I, we used a method based on enzyme-linked immunosorbent assay with subsequent statistical processing of the results using the MedStat package. Research results and their discussion. When conducting studies using express tests, the difference in the qualitative indicators of the biochemical marker Troponin I, depending on the causes and genesis of death: mechanical asphyxia, acute and chronic ischemic heart disease, was not found. Nevertheless, a difference was revealed in the quantitative indicators of the biochemical marker Troponin I, depending on the causes and genesis of death: mechanical asphyxia, acute and chronic ischemic heart disease at the significance level p = 0.008 (the average value of the quantitative content of Troponin I in the blood of deaths from mechanical ml ± 4.4 ng / ml; in the blood of those who died from acute and chronic ischemic heart disease 45.62 ng / ml ± 22.4 ng / ml). Conclusions. Thus, in the course of the studies, the inexpediency of determining the qualitative indicators of the biochemical marker Troponin I using express tests was proved and the expediency of using changes in the quantitative indicators of Troponin I to determine the asphyxia state in mechanical asphyxia and differential diagnosis of cases of violent death (mechanical asphyxia) was substantiated. death (acute and chronic ischemic heart disease), which makes it possible to increase the efficiency and reliability of forensic medical examinations.