Open Access"IMMUNOCOMPETENT LIVER CELLS IN THE PATHOGENESIS OF FIBROSIS DURING CHEMICAL CASTRATION OF MALE RATS"
Author(s) -
M. V. Rud
Publication year - 2021
Publication title -
aktualʹnì problemi sučasnoï medicini: vìsnik ukraïnsʹkoï medičnoï stomatologìčnoï akademì
Language(s) - English
Resource type - Journals
eISSN - 2077-1126
pISSN - 2077-1096
DOI - 10.31718/2077-1096.21.2.203
Subject(s) - population , cirrhosis , macrophage , biology , mononuclear phagocyte system , antigen , fibrosis , antigen presentation , kupffer cell , immunology , cancer research , pathology , medicine , immune system , t cell , in vitro , biochemistry , environmental health
Hepatocytes make up only about 2/3 of the total liver cell population. The population of nonparenchymal antigen-presenting cells includes Kupffer cells that are part of the reticuloendothelial system, sinusoidal endothelial cells of the liver and dendritic cells. All three types of antigen-presenting cells are thought to be crucial for maintaining tolerance in non-inflammatory conditions. Macrophages play a key role in creating the body's line of defense. The implementation of this function is carried out due to the direct mechanism of action and also due to indirect - processing and presentation of antigenic determinants to T-lymphocytes. How specific populations of macrophages contribute to the development of diseases and regeneration of the liver is the subject of constant debate. Characterization of human macrophage populations provides a valuable basis for studying their role in liver pathology. Each subtype of tissue macrophage has its own unique gene expression profile, which allows it to function in synergy with the tissue in which it is located. As a result of activation of Kupffer and Ito cells, mainly due to their production of collagen, the process of liver fibrogenesis is initiated. Liver disease models in mice that block androgen receptors have shown that androgen / androgen receptor signaling inhibits the development of steatosis, viral hepatitis, and cirrhosis. Preliminary clinical trials have shown that drugs that inhibit the activity of sex steroids can control the growth and invasiveness of hepatocellular carcinoma in certain patients. Thus, the aim of our further study was to elucidate the qualitative and quantitative changes in immunocompetent liver cells during chemical castration of male rats caused by the introduction of a solution of triptorelin acetate at different time intervals.