ACTIVITY OF ANTIOXIDANT PROTECTION ENZYMES IN BLOOD AS A MARKER OF NEPHROPROTECTIVE EFFECT BY SODIUM POLY-(2,5-DIHYDROXYPHENYLEN)-4-THIOSULFATE ACID

The article presents the results of assessing the activity of catalase and superoxide dismutase enzymes in the blood as markers of the nephroprotective effect by sodium poly-(2,5-dihydroxyphenylen)-4-thiosulfate acid under conditions of ethylene glycol and glycerol acute kidney injury and gentamicin-induced nephropathy. The studies were conducted on 96 white mature, full-grown non-linear rats of both sexes weighting 180-200 grams. Models of acute kidney pathology in the rats were reproduced in accordance with the methodological recommendations of the Ministry of Health of Ukraine. Blood activity of superoxide dismutase and catalase was determined spectrophotometrically with standard methods. It has been established that oxidative stress plays a significant role in the pathogenesis of ethylene glycol and glycerol acute kidney damage and gentamicin nephropathy, as evidenced by significant changes in the antioxidant defence system, and namely by inhibition of the activity of superoxide dismutase and catalase enzymes. Under the conditions of acute kidney injury and nephropathy, the sodium poly-(2,5-dihydroxyphenylen)-4-thiosulfate acid contributed to the activation of superoxide dismutase and catalase better than reference medicines as plan-based chophytol, and mexidol as antihypoxant and thiotriazoline as antioxydant. Thus, the antioxidant enzymes as superoxide dismutase and catalase can serve as markers of the nephroprotective effect produced by the preparation of sodium poly-(2,5-dihydroxyphenylen)-4-thiosulfate acid. And therefore, we suggest sodium poly-(2,5-dihydroxyphenylen)-4-thiosulfate acid exhibiting antihypoxic, cytoprotective, antioxidant properties is a promising drug for the treatment of acute kidney diseases.