THE EFFECT OF ANTIOXIDANT THERAPY ON THE SEVERITY OF THE COURSE, THERAPY EFFICACY AND DURATION OF REMISSION IN PATIENTS WITH PSORIASIS

The prevalence of psoriasis has accentuated the high relevance of searching new approaches towards its treatments. This article describes the connection between the development of the clinical picture and lipid peroxidation, and studies the expediency of using drugs with antioxidant properties as a component of the treatment. The products of lipid peroxidation regulate cell proliferation and permeability of cell membranes, thus the function and structure of the skin is directly dependent on the level of lipids and phospholipids. Patients with either mild or severe psoriasis have been found out to demonstrate some changes in the blood serum: increased cholesterol, triglycerides and free fatty acids, as well as a change in the ratio of the fractional content of phospholipids in erythrocyte membranes. Taking into account the above mentioned factors of psoriasis, we can suggest that it would be reasonable to include antioxidants into the integrated therapy. Antioxidants are the group of biologically active substances that possess an ability to interact with various reactogenic oxidants, reactive oxygen species and other free radicals that leads to their full or partial inactivation. During this study resveratrol was added to standard psoriasis therapy. The scope of laboratory research included: diagnosis of changes in the blood biochemical analysis taken on an empty stomach in the morning to investigate the content of total protein, albumin, bilirubin, low and high density lipids, phospholipids, cholesterol, alanine aminotransferase, aspartate aminotransferase. It has been found out the reduction of symptom in the patients who received complex therapy modified with resveratrol was more marked than in patients who received standard therapy only. A more intensive decrease in infiltration, erythema, desquamation, and itching has been clinically observed as well.