ANALYSIS OF CHANGES IN TNF-Α, IL-6, IL-8 IN PATIENTS WITH INCREASED BODY MASS INDEX AND POLYTRAUMA

It is known that adipose tissue is the site of the formation of proinflammatory cytokines - tumour necrosis factor alpha (TNF-α) and some interleukins. The aim of our work was to analyze changes in the level of TNF-α, interleukins 6, 8 (IL-6, IL-8) in the blood serum of 224 patients with an increased body mass index who had a polytrauma with different initial body mass index through the period of 1 day – 1 year since the moment of injury. It has been revealed that patients with a BMI of ≤ 29.9 are characterized by an increase in the control numbers of IL-6 from day 1 to day 7, an increase in the level of IL-8 from day 1 to day 3, and an increase in the level of TNF-α from day 1 to day 3. For patients with obesity II - III, an excess of IL-6 was detected from day 1 to day 30, an increase in the level of IL-8 from day 1 to day 3, and an increase in the level of TNF-α from day 1 to day 30. Patients with a BMI ≥ 40.0 demonstrate an increase in the IL-6 control figures during the year from the moment of receiving polytrauma, followed by a decrease to the 360th day, an increase in the level of IL-8 from day 1 to day 3, an increase in the TNF level -α from the day 1 to day 3. It has been found out that the indicators we studied directly reflect the adaptation status of patients with increased body mass index and polytrauma, which presentation depends on the body mass index, that is, on the amount of adipose tissue. It is apparent that it is pro-inflammatory cytokinins - IL-6, IL-8, TNF-α that are able to simulate the expected result, as they determine vigilance, stimulation or inhibition of growth, including immune cells, their differentiation, and functional activation.